This blueberry cream cheese loaf is your answer when you want a sweet breakfast or after-dinner dessert. Packed with juicy blueberries, swirls of creamy cheesecake filling, and topped with a buttery cinnamon streusel, this loaf is soft, moist, and loaded with flavor in every bite.

Whether you’re serving it for breakfast, brunch, dessert, or alongside your afternoon coffee, this blueberry cream cheese loaf delivers bakery-quality results right from your own kitchen.
If you love sweet treats that double as breakfast or dessert, try my blueberry crescent cream cheese muffins, mini cinnamon rolls, or banana nut muffins.
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Why You’ll Love This Recipe
- Moist and tender texture
- Loaded with fresh blueberries
- Rich cream cheese swirls throughout
- Sweet cinnamon streusel topping
- Perfect for breakfast, brunch, or dessert
- Easy to make with simple ingredients
- Great for holidays, gatherings, and gifting
Key Ingredients
I’ve included a list of this recipe’s most important ingredients here. You can find a complete list, along with amounts, in the recipe card at the bottom of the post.

- Blueberries: Add bursts of juicy sweetness and fresh flavor throughout every slice.
- Cream Cheese: Creates the rich, creamy swirl that gives this loaf a cheesecake-like feel.
- Sour Cream: Helps keep the loaf incredibly moist and tender while adding a subtle tang that balances the sweetness.
- Cinnamon: The key flavor in the streusel topping adds warmth, making the loaf taste cozy and comforting.
Variations
- Lemon Blueberry Cream Cheese Loaf: Add 1 tablespoon lemon zest to the batter for a bright citrus flavor.
- Berry Loaf: Use your favorite berries in place of blueberries.
- Mixed Berry Loaf: Try a mix of your favorite berries.
- Nutty Blueberry Loaf: Chopped pecans or walnuts add delicious crunch and texture.
- Extra Streusel: Double the streusel topping for a thick, crumbly finish.
How to Make Blueberry Cream Cheese Loaf
I’ve provided an overview of the recipe here, but you can find the exact instructions in the recipe card at the bottom of the post.

1: Cream the butter and brown sugar until light and fluffy. Then, mix in the remaining wet batter ingredients.

2: Toss the blueberries with flour and set aside. Whisk the dry batter ingredients and mix them into the wet ingredients until just combined.

3: Fold in the blueberries.

4: Beat the cream cheese until smooth and fluffy. Then, beat in the remaining ingredients until creamy.

5: Mix the streusel ingredients until crumbly.

6: Pour half the batter into a prepared loaf pan. Then, add half the cream cheese mix and gently swirl it into the batter with a toothpick or knife. Repeat.

7: Top the loaf with the streusel.

8: Finally, bake until a toothpick inserted into the center comes out clean. Cool, slice, and enjoy.
Expert Tips
- Frozen blueberries work well out of season. Don’t thaw them before baking.
- Greek yogurt is a great substitute for sour cream if you don’t have it on hand.
- Mix the batter just until combined to keep the loaf soft and tender.
- Tossing blueberries in flour helps distribute them evenly throughout the loaf.
- Allowing the loaf to cool helps the cream cheese filling set properly.
- Spray the loaf pan evenly with cooking spray, but don’t use so much that it pools.
- Cover the streusel with foil if it starts to get too brown.
Blueberry Cream Cheese Loaf FAQs
Unless otherwise stated in the recipe, frozen and fresh blueberries can be used interchangeably in baked goods. Add them directly to the batter without thawing to help prevent excess moisture and color bleeding.
Tossing the blueberries in flour helps keep them evenly distributed throughout the loaf and prevents them from sinking to the bottom during baking.
Insert a toothpick into the center of the loaf. If it comes out clean or with a few moist crumbs, the loaf is done. Be careful to avoid testing directly in a cream cheese swirl.
Overmixing the batter can result in a dense texture. Mix only until the ingredients are combined to keep the loaf soft and tender.
Because the loaf contains a cream cheese filling, it should be stored in an airtight container in the refrigerator for up to 5 days.
Yes, you can. Wrap either the entire loaf or individual slices in plastic wrap and freeze for up to 3 months in an airtight, freezer-safe container.

Delicious Pairings for Blueberry Cheesecake Bread
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Blueberry Cream Cheese Loaf
Ingredients
Blueberry Loaf
- 2 cups all-purpose flour
- 1 teaspoon baking soda
- ¼ teaspoon salt
- ½ cup butter, softened
- ⅔ cup brown sugar
- 2 large eggs
- 1 cup sour cream
- 1 teaspoon vanilla extract
- 1 cup blueberries
Cream Cheese Filling
- 8 ounces cream cheese
- 2 egg yolks
- 2 tablespoons sour cream
- 2 tablespoons granulated sugar
Streusel Topping
- ¼ cup all-purpose flour
- ¼ cup brown sugar
- ¼ teaspoon cinnamon
- ⅛ teaspoon salt
- 2 tablespoons butter, cold, diced small
Instructions
- Preheat the oven to 350°.
- Spray a 9 x 5 loaf pan with non-stick cooking spray. Set aside.
Blueberry Loaf
- Place blueberries in a small bowl and add ¼ cup of flour. Stir to fully coat blueberries and set aside.
- In a large bowl, cream together the butter and sugar.
- Add in eggs, sour cream, and vanilla extract.
- Add in the flour, baking soda, and salt. Stir until just combined.
- Fold in the flour covered blueberries.
Cream Cheese Filling
- In a medium mixing bowl, beat the cream cheese until light and fluffy (about 2-3 minutes).
- Add in the egg yolks, sour cream, and sugar. Beat until well combined and smooth. Set aside.
Streusel Topping
- In a small bowl, combine the brown sugar, flour, cinnamon, salt, and butter.
- Using a fork, or clean hands, mix the butter in with the dry ingredients until fully incorporated.
- Fill the loaf pan ½ way, add in ½ of the cream cheese mixture and use a toothpick or knife to swirl into the batter.
- Add the remainder of the batter on top and then the rest of cream cheese, and swirl into the batter.
- Now, top the loaf with a generous amount of streusel topping and bake in the preheated oven for 65-76 minutes until a toothpick inserted comes out clean.
Notes
- Frozen blueberries work well out of season. Don’t thaw them before baking.
- Greek yogurt is a great substitute for sour cream if you don’t have it on hand.
- Mix the batter just until combined to keep the loaf soft and tender.
- Tossing blueberries in flour helps distribute them evenly throughout the loaf.
- Allowing the loaf to cool helps the cream cheese filling set properly.
- Spray the loaf pan evenly with cooking spray, but don’t use so much that it pools.
- If the streusel topping starts to brown too much, lightly cover with aluminum foil and continue baking.
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