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4.45 from 225 votes

Italian Sausage Penne Casserole

Prep Time20 mins
Cook Time1 hr
Total Time1 hr 20 mins
Course: Comfort Food, Dinner, Main Meal
Cuisine: Italian
Servings: 6 people
Author: Terri


  • 1 16 oz box of Penne pasta
  • 2 lb packages of Hot Italian Sausage, can use Sweet Italian instead
  • 24 oz mozzarella cheese, grated
  • 1 medium onion, chopped
  • 5 cloves of garlic, chopped
  • 1 28 oz can of diced tomatoes
  • 1 1/2 tsp basil
  • 1 1/2 tsp oregano
  • Salt and pepper, to taste


  • Preheat oven to 350° and spray a 3 quart casserole dish with a non stick spray. Set aside. 
  • Remove sausage from casing and add to large skillet.
  • Crumble and cook over medium heat until done.
  • Drain grease from sausage, reserving 2 tablespoons of grease. Set sausage aside.
  • Spoon 2 tablespoons of grease back to pan, add chopped onions and garlic and saute until onions are translucent.
  • Pour diced tomatoes into skillet with the onions and garlic.
  • Add basil, oregano, salt and pepper.
  • Cook for about 5 minutes over medium heat.
  • Add Italian sausage back to skillet and bring to a boil.
  • Cover and simmer on low for approximately 20 - 30 minutes, stirring occasionally. 
  • Cook pasta according to package directions for al dente.
  • Drain, rinse and place pasta back in pan.
  • Add sausage mixture to pan with pasta.
  • Add 1/2 of the mozzarella cheese to the pan and stir well until melted.
  • Place 1/2 of the meat and pasta mixture into prepared casserole dish, sprinkle with cheese, add the rest of the meat and pasta, top with remaining cheese, cover with foil bake until cheese is bubbly and heated through, approximately 30 minutes. Can remove foil and bake the cheese a bit more. 
  • Serve with salad and garlic bread.